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Portrait of Sophia Zackrisson. Photo

Sophia Zackrisson

Research group manager, Principal investigator, Professor, MD

Portrait of Sophia Zackrisson. Photo

Advancing breast tissue imaging with an ultrasound optical tomography (UOT) approach

Author

  • Maria Ruchkina
  • Akvile Zabiliute-Karaliune
  • Egle Bukarte
  • Adam Kinos
  • David Hill
  • Alexander Bengtsson
  • Kevin Shortiss
  • Nina Reistad
  • Lars Rippe
  • Johannes Swartling
  • Sophia Zackrisson
  • Predrag Bakic
  • Laszlo Kovacs
  • Zsolt Kis
  • Zsuzsanna Szaller
  • Krisztian Lengyel
  • Charles Thiel
  • Stefan Kröll

Editor

  • Valery V. Tuchin
  • Walter C.P.M. Blondel
  • Zeev Zalevsky

Summary, in English

Each year, about 30% of all newly diagnosed cancer cases in women worldwide are breast cancers [1]. One of the most common techniques for breast cancer diagnosis is mammography. However, this technique provides limited functional information regarding breast tissue morphology. In cases of suspected malignancy invasive techniques such as biopsy are implemented.
In this work an optical deep tissue imaging technique called ultrasound optical tomography (UOT) which combines laser light and ultrasound is implemented for a non-invasive lesion (tumour) characterization in breast tissue.
The experiments were performed using 794 nm laser wavelength, 6 MHz ultrasound frequency and a narrowband spectral filter material, Tm3+:LiNbO3. The measurements were carried out in 5 cm thick agar phantoms using a range of tumor mimicking inclusions of 3 different sizes.
This work is the first deep tissue imaging demonstration using UOT at tissue relevant wavelengths. Current results indicate that the UOT technique can become an important and valuable tool for lesion characterization in breast tissue.

Department/s

  • LTH Profile Area: Nanoscience and Semiconductor Technology
  • LTH Profile Area: Engineering Health
  • LU Profile Area: Light and Materials
  • LTH Profile Area: Photon Science and Technology
  • NanoLund: Centre for Nanoscience
  • Atomic Physics
  • Chemical Physics
  • Centre for Environmental and Climate Science (CEC)
  • LUCC: Lund University Cancer Centre
  • EpiHealth: Epidemiology for Health
  • Radiology Diagnostics, Malmö

Publishing year

2024

Language

English

Pages

1301006-1301006

Publication/Series

Tissue Optics and Photonics III : PROCEEDINGS VOLUME 13010 SPIE PHOTONICS EUROPE | 7-12 APRIL 2024

Volume

13010

Document type

Conference paper

Publisher

SPIE

Topic

  • Radiology, Nuclear Medicine and Medical Imaging
  • Atom and Molecular Physics and Optics

Keywords

  • breast cancer
  • bio-medical imaging
  • diagnosis
  • ultrasound optical tomography
  • deep tissue imaging
  • acousto-optic effect
  • spectral-hole-burning filters
  • rare-earth-ion-doped crystals

Conference name

SPIE Photonics Europe, 2024, Strasbourg, France

Conference date

2024-06-18

Conference place

Strasbourg, France

Status

Published

Research group

  • Radiology Diagnostics, Malmö