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Portrait of Sophia Zackrisson. Photo

Sophia Zackrisson

Research group manager, Principal investigator, Professor, MD

Portrait of Sophia Zackrisson. Photo

14C bomb-pulse dating and stable isotope analysis for growth rate and dietary information in breast cancer?

Author

  • K. Lång
  • K. Eriksson Stenström
  • A. Rosso
  • M. Bech
  • S. Zackrisson
  • D. Graubau
  • S. Mattsson

Summary, in English

The purpose of this study was to perform an initial investigation of the possibility to determine breast cancer growth rate with 14C bomb-pulse dating. Tissues from 11 breast cancers, diagnosed in 1983, were retrieved from a regional biobank. The estimated average age of the majority of the samples overlapped the year of collection (1983) within 3σ. Thus, this first study of tumour tissue has not yet demonstrated that 14C bomb-pulse dating can obtain information on the growth of breast cancer. However, with further refinement, involving extraction of cell types and components, there is a possibility that fundamental knowledge of tumour biology might still be gained by the bomb-pulse technique. Additionally, δ13C and δ15N analyses were performed to obtain dietary and metabolic information, and to serve as a base for improvement of the age determination.

Department/s

  • Department of Translational Medicine
  • Department of Physics
  • Department of Clinical Sciences, Lund
  • BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation

Publishing year

2016-06

Language

English

Pages

158-164

Publication/Series

Radiation Protection Dosimetry

Volume

169

Issue

1

Document type

Journal article

Publisher

Oxford University Press

Topic

  • Cancer and Oncology
  • Radiology, Nuclear Medicine and Medical Imaging
  • Other Physics Topics

Status

Published

ISBN/ISSN/Other

  • ISSN: 0144-8420