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Portrait of Sophia Zackrisson. Photo

Sophia Zackrisson

Research group manager, Principal investigator, Professor, MD

Portrait of Sophia Zackrisson. Photo

Rate of over-diagnosis of breast cancer 15 years after end of Malmö mammographic screening trial: follow-up study.

Author

  • Sophia Zackrisson
  • Ingvar Andersson
  • Lars Janzon
  • Jonas Manjer
  • Jens Peter Garne

Summary, in English

Objective To evaluate the rate of over-diagnosis of breast cancer 15 years after the end of the Malmo mammographic screening trial. Design Follow-up Study. Setting Malmo, Sweden. Subjects 42 283 women aged 45-69 years at randomisation. Interventions Screening for breast cancer with mammography or not (controls). Screening was offered at end of randomisation design to both groups aged 45-54 at randomisation but not to groups aged 55-69 at randomisation. Main outcome measures Rate of over-diagnosis of breast cancer (in situ and invasive), calculated as incidence in the invited and control groups, during period of randomised design (period 1), during period randomised design ended (period 2), and at end of follow-up. Results In women aged 55-69 years at randomisation the relative rates of over-diagnosis of breast cancer (95% confidence intervals) were 1.32 (1.14 to 1.53) for period 1, 0.92 (0.79 to 1.06) for period 2, and 1.10 (0.99 to 1.22) at the end of follow-up. Conclusion Conclusions on over-diagnosis of breast cancer in the Malmo mammographic screening trial can be drawn mainly in women aged 55-69 years at randomisation whose control groups were never screened. Fifteen years after die trial ended the rate of over-diagnosis of breast cancer was 10% in this age group.

Department/s

  • Cardiovascular Research - Epidemiology
  • Radiology Diagnostics, Malmö
  • Surgery

Publishing year

2006

Language

English

Pages

689-691

Publication/Series

BMJ

Volume

332

Issue

7543

Document type

Journal article

Publisher

BMJ Publishing Group

Topic

  • Clinical Medicine

Status

Published

Research group

  • Cardiovascular Research - Epidemiology
  • Radiology Diagnostics, Malmö
  • Surgery

ISBN/ISSN/Other

  • ISSN: 0959-8138