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Portrait of Sophia Zackrisson. Photo

Sophia Zackrisson

Research group manager, Principal investigator, Professor, MD

Portrait of Sophia Zackrisson. Photo

Computer model of mechanical imaging acquisition for virtual clinical trials

Author

  • Rebecca Axelsson
  • Hanna Isaksson
  • Sophia Zackrisson
  • Anders Tingberg
  • Predrag Bakic
  • Magnus Dustler

Editor

  • Hilde Bosmans
  • Wei Zhao
  • Lifeng Yu

Summary, in English

Malignant breast tumours can be distinguished from benign lesions and normal tissue based on their mechanical properties. Our pilot studies have demonstrated the potential of using Mechanical Imaging (MI) combined with mammography to reduce recalls and false positives in breast cancer screening by more accurately identifying benign lesions. To enable further optimization of MI we propose a computer simulation of the MI acquisition, for use in a Virtual Clinical Trial (VCT) framework. VCTs are computer simulated clinical trials used to efficiently evaluate clinical imaging systems. A linear elastic finite element (FE) model of the breast under dynamic compression was implemented using an open-source FE solver. A spherical tumour (15 mm in diameter) was inserted into the simulated predominantly adipose breast. The location and stiffness of the tumour was varied. The average stress on the compressed breast surface was calculated and compared with the local average stress at the tumour location and the Relative Mean Pressure over lesion Area (RMPA) was calculated. Preliminary results were within a realistic range with an average stress on the breast (tumour) of 5.9-16.6 kPa which is in agreement with published values between 1.0 - 22.5 kPa. This corresponds to RMPA values of 0.96-2.15 depending on stiffness and location of the tumour. This can lead to more detailed validation of various MI acquisition schemes through VCTs before their use in clinical studies.

Department/s

  • LUCC: Lund University Cancer Centre
  • Medical Radiation Physics, Lund
  • Department of Biomedical Engineering
  • EpiHealth: Epidemiology for Health
  • Radiology Diagnostics, Malmö
  • Medical Radiation Physics, Malmö

Publishing year

2021

Language

English

Pages

1-115950

Publication/Series

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Volume

11595

Document type

Conference paper

Publisher

SPIE

Topic

  • Cancer and Oncology
  • Radiology, Nuclear Medicine and Medical Imaging

Keywords

  • Breast cancer screening
  • Finite element method
  • Mechanical imaging
  • Virtual clinical trials

Conference name

Medical Imaging 2021: Physics of Medical Imaging

Conference date

2021-02-15 - 2021-02-19

Conference place

Virtual, Online, United States

Status

Published

Project

  • Simultaneous Digital Breast Tomosynthesis and Mechanical Imaging

Research group

  • Radiology Diagnostics, Malmö
  • Medical Radiation Physics, Malmö

ISBN/ISSN/Other

  • ISSN: 1605-7422
  • ISBN: 9781510640191