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Portrait of Sophia Zackrisson. Photo

Sophia Zackrisson

Research group manager, Principal investigator, Professor, MD

Portrait of Sophia Zackrisson. Photo

Rim Sign in Breast Lesions on Diffusion-Weighted Magnetic Resonance Imaging: Diagnostic Accuracy and Clinical Usefulness

Author

  • Bong Joo Kang
  • Jafi Alyssa Lipson
  • Katie RoseMary Planey
  • Sophia Zackrisson
  • Debra M. Ikeda
  • Jennifer Kao
  • Sunita Pal
  • Catherine J. Moran
  • Bruce Lewis Daniel

Summary, in English

PurposeTo investigate the diagnostic accuracy and clinical usefulness of the rim sign in breast lesions observed in diffusion-weighted magnetic resonance imaging (DWI). Materials and MethodsThe magnetic resonance imaging (MRI) findings of 98 pathologically confirmed lesions (62 malignant and 36 benign) in 84 patients were included. Five breast radiologists were asked to independently review the breast MRI results, to grade the degree of high peripheral signal, the rim sign, in the DWI, and to confirm the mean apparent diffusion coefficient (ADC(mean)) values. We analyzed the diagnostic accuracy and compared the consensus (when 4 of 5 independent reviewers agreed) results of the rim sign with the ADC(mean) values. Additionally, we evaluated the correlation between the dynamic contrast-enhanced (DCE)-MRI morphologic appearance and DWI rim sign. ResultsAccording to the consensus results, the rim sign in DWI was observed on 59.7% of malignant lesions and 19.4% of benign lesions. The sensitivity, specificity, and area under the curve (AUC) value for the rim sign in DWI were 59.7%, 80.6%, and 0.701, respectively. The sensitivity, specificity, and AUC value for the ADC(mean) value (criteria 1.46 x 10(-3) mm(2)/sec) were 82.3%, 63.9%, and 0.731, respectively. Based on consensus, no correlation was observed between the DCE-MRI and DWI rim signs. ConclusionIn DWI, a high-signal rim is a valuable morphological feature for improving specificity in DWI. J. Magn. Reson. Imaging 2015;41:616-623. (c) 2014 Wiley Periodicals, Inc.

Department/s

  • Radiology Diagnostics, Malmö
  • BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation

Publishing year

2015

Language

English

Pages

616-623

Publication/Series

Journal of Magnetic Resonance Imaging

Volume

41

Issue

3

Document type

Journal article

Publisher

John Wiley & Sons Inc.

Topic

  • Radiology, Nuclear Medicine and Medical Imaging

Keywords

  • breast cancer
  • magnetic resonance imaging
  • diffusion-weighted image

Status

Published

Research group

  • Radiology Diagnostics, Malmö

ISBN/ISSN/Other

  • ISSN: 1522-2586