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Portrait of Sophia Zackrisson. Photo

Sophia Zackrisson

Research group manager, Principal investigator, Professor, MD

Portrait of Sophia Zackrisson. Photo

Mammographic density changes during neoadjuvant breast cancer treatment : NeoDense, a prospective study in Sweden

Author

  • Ida Skarping
  • Daniel Förnvik
  • Uffe Heide-Jørgensen
  • Hanna Sartor
  • Per Hall
  • Sophia Zackrisson
  • Signe Borgquist

Summary, in English

Objectives: To assess if mammographic density (MD) changes during neoadjuvant breast cancer treatment and is predictive of a pathological complete response (pCR). Methods: We prospectively included 200 breast cancer patients assigned to neoadjuvant chemotherapy (NACT) in the NeoDense study (2014–2019). Raw data mammograms were used to assess MD with a fully automated volumetric method and radiologists categorized MD using the Breast Imaging-Reporting and Data System (BI-RADS), 5th Edition. Logistic regression was used to calculate odds ratios (OR) for pCR comparing BI-RADS categories c vs. a, b, and d as well as with a 0.5% change in percent dense volume adjusting for baseline characteristics. Results: The overall median age was 53.1 years, and 48% of study participants were premenopausal pre-NACT. A total of 23% (N = 45) of the patients accomplished pCR following NACT. Patients with very dense breasts (BI-RADS d) were more likely to have a positive axillary lymph node status at diagnosis: 89% of the patients with very dense breasts compared to 72% in the entire cohort. A total of 74% of patients decreased their absolute dense volume during NACT. The likelihood of accomplishing pCR following NACT was independent of volumetric MD at diagnosis and change in volumetric MD during treatment. No trend was observed between decreasing density according to BI-RADS and the likelihood of accomplishing pCR following NACT. Conclusions: The majority of patients decreased their MD during NACT. We found no evidence of MD as a predictive marker of pCR in the neoadjuvant setting.

Department/s

  • LUCC: Lund University Cancer Centre
  • Breast cancer prevention & intervention
  • Medical Radiation Physics, Malmö
  • Radiology Diagnostics, Malmö
  • EpiHealth: Epidemiology for Health

Publishing year

2020

Language

English

Pages

33-41

Publication/Series

Breast

Volume

53

Document type

Journal article

Publisher

Churchill Livingstone

Topic

  • Cancer and Oncology

Keywords

  • Breast cancer
  • Breast density
  • Mammography
  • Neoadjuvant therapy

Status

Published

Research group

  • Breast cancer prevention & intervention
  • Medical Radiation Physics, Malmö
  • Radiology Diagnostics, Malmö

ISBN/ISSN/Other

  • ISSN: 0960-9776