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Portrait of Sophia Zackrisson. Photo

Sophia Zackrisson

Research group manager, Principal investigator, Professor, MD

Portrait of Sophia Zackrisson. Photo

Airspace dimension assessment with nanoparticles as a proposed biomarker for emphysema

Author

  • H. Laura Aaltonen
  • Madeleine Petersson Sjögren
  • Jonas K.F. Jakobsson
  • Hanna Nicklasson
  • Sandra Diaz
  • Francisco Sánchez Montiel
  • Sophia Zackrisson
  • Veronica Ideböhn
  • Gunnar Engström
  • Jakob Löndahl
  • Per Wollmer
Show all

Summary, in English

Airspace dimension assessment with nanoparticles (AiDA) is a novel method to measure distal airspace radius non-invasively. In this study, AiDA radii were measured in 618 individuals from the population-based Swedish CArdiopulmonary BioImaging Study, SCAPIS. Subjects with emphysema detected by computed tomography were compared to non-emphysematous subjects. The 47 individuals with mainly mild-to-moderate visually detected emphysema had significantly larger AiDA radii, compared with non-emphysematous subjects (326±48 μm vs 291±36 μm); OR for emphysema per 10 μm: 1.22 (1.13-1.30, p<0.0001). Emphysema according to CT densitometry was similarly associated with larger radii compared with non-emphysematous CT examinations (316±41 μm vs 291 μm±26 μm); OR per 10 μm: 1.16 (1.08-1.24, p<0.0001). The results are in line with comparable studies. The results show that AiDA is a potential biomarker for emphysema in individuals in the general population.

Department/s

  • Radiology Diagnostics, Malmö
  • NanoLund: Centre for Nanoscience
  • Ergonomics and Aerosol Technology
  • Department of Design Sciences
  • EpiHealth: Epidemiology for Health
  • Cardiovascular Research - Epidemiology
  • Clinical Microbiology, Malmö

Publishing year

2021

Language

English

Pages

1040-1043

Publication/Series

Thorax

Volume

76

Issue

10

Document type

Journal article

Publisher

BMJ Publishing Group

Topic

  • Respiratory Medicine and Allergy
  • Radiology, Nuclear Medicine and Medical Imaging

Keywords

  • emphysema
  • exhaled airway markers
  • imaging/CT MRI
  • respiratory measurement

Status

Published

Research group

  • Radiology Diagnostics, Malmö
  • Cardiovascular Research - Epidemiology
  • Clinical Microbiology, Malmö

ISBN/ISSN/Other

  • ISSN: 0040-6376