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Portrait of Sophia Zackrisson. Photo

Sophia Zackrisson

Research group manager, Principal investigator, Professor, MD

Portrait of Sophia Zackrisson. Photo

Alignment of clinical breast tomosynthesis and mechanical images : The effect of the variation in shift and rotation

Author

  • Predrag R. Bakic
  • Sophia Zackrisson
  • Anders Tingberg
  • Magnus Dustler

Editor

  • Maryellen L. Giger
  • Heather M. Whitney
  • Karen Drukker
  • Hui Li

Summary, in English

Simultaneous digital breast tomosynthesis and mechanical imaging (DBTMI), a novel screening approach, combines anatomic DBT with functional analysis of the stress distribution on the compressed breast by mechanical imaging (MI). Preliminary studies suggest potential to reduce false positive findings. DBTMI requires to align DBT and MI images. In this study, we have analyzed robustness to alignment variations in clinical DBTMI data. Our preliminary retrospective analysis included DBTMI of 31 women recalled from screening. We analyzed two aspects of image alignment: rotation and shift. To analyze the shift, we varied the position of suspected abnormality for ±1 cm in horizontal or vertical direction. To analyze the rotation, we varied the angle by ±1 degree between radiographic and MI images of 18 women. We compared the relative mean pressure at the lesion area (RMPA) before and after variation. Varying the shift, we observed 14.3%±12.2% difference in RMPA. Averaged separately over biopsy confirmed benign and malignant lesions, 16.2%±14.3% and 12.4%±10.2% difference was observed, respectively. In nine of 31 analyzed datasets, the shift could potentially change the clinical findings. Varying the rotation, we observed 6.4%±4.9% difference in RMPA. Averaged over biopsy confirmed benign and malignant lesions, yielded 5.8%±4.5% and 6.4%±4.8% difference, respectively. In two of 18 DBTMI datasets, the rotational variation could change the clinical findings. The larger effect of the shift may be caused by a relatively large shift variation (±1 cm) compared to the size of detected abnormalities. Analysis of more clinical DBTMI datasets and simulation studies are ongoing.

Department/s

  • LUCC: Lund University Cancer Centre
  • Radiology Diagnostics, Malmö
  • LU Profile Area: Light and Materials
  • LTH Profile Area: Photon Science and Technology
  • EpiHealth: Epidemiology for Health
  • Medical Radiation Physics, Malmö

Publishing year

2024

Language

English

Publication/Series

Proceedings of SPIE - The International Society for Optical Engineering

Volume

13174

Document type

Conference paper

Publisher

SPIE

Topic

  • Radiology, Nuclear Medicine and Medical Imaging

Keywords

  • Breast cancer screening
  • image alignment
  • mechanical imaging (MI)
  • performance evaluation
  • simultaneous breast tomosynthesis and MI

Conference name

17th International Workshop on Breast Imaging, IWBI 2024

Conference date

2024-06-09 - 2024-06-12

Conference place

Chicago, United States

Status

Published

Research group

  • Radiology Diagnostics, Malmö
  • Medical Radiation Physics, Malmö

ISBN/ISSN/Other

  • ISSN: 1996-756X
  • ISSN: 0277-786X
  • ISBN: 9781510680203