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Portrait of Magnus Dustler. Photo

Magnus Dustler

Researcher

Portrait of Magnus Dustler. Photo

No evidence for shedding of circulating tumor cells to the peripheral venous blood as a result of mammographic breast compression.

Author

  • Daniel Förnvik
  • Ingvar Andersson
  • Magnus Dustler
  • Roy Ehrnström
  • Lisa Rydén
  • Anders Tingberg
  • Sophia Zackrisson
  • Kristina Aaltonen

Summary, in English

This pilot study aimed to investigate whether mammographic compression procedures might cause shedding of tumor cells into the circulatory system as reflected by circulating tumor cell (CTC) count in peripheral venous blood samples. From March to October 2012, 24 subjects with strong suspicion of breast malignancy were included in the study. Peripheral blood samples were acquired before and after mammography. Enumeration of CTCs in the blood samples was performed using the CellSearch(®) system. The pressure distribution over the tumor-containing breast was measured using thin pressure sensors. The median age was 66.5 years (range, 51-87 years). In 22 of the 24 subjects, breast cancer was subsequently confirmed. The difference between the average mean tumor pressure 6.8 ± 5.3 kPa (range, 1.0-22.5 kPa) and the average mean breast pressure 3.4 ± 1.6 kPa (range, 1.5-7.1 kPa) was statistically significant (p < 0.001), confirming that there was increased pressure over the tumor. The median pathological tumor size was 19 mm (range, 9-30 mm). Four subjects (17 %) were CTC positive before compression and two of these (8 %) were also CTC positive after compression. A total of seven CTCs were isolated with a mean size of 8 × 6 μm(2) (range of the longest diameter, 5-12 μm). The study supports the view that mammography is a safe procedure from the point of view of tumor cell shedding to the peripheral blood.

Department/s

  • Medical Radiation Physics, Malmö
  • Radiology Diagnostics, Malmö
  • Pathology, Malmö
  • Surgery (Lund)
  • Breastcancer-genetics
  • The Liquid Biopsy and Tumor Progression in Breast Cancer
  • BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation

Publishing year

2013

Language

English

Pages

187-195

Publication/Series

Breast Cancer Research and Treatment

Volume

141

Issue

2

Document type

Journal article

Publisher

Springer

Topic

  • Cancer and Oncology

Status

Published

Project

  • CTC-MBC, Circulating Tumor Cells in Metastatic Breast Cancer

Research group

  • Medical Radiation Physics, Malmö
  • Radiology Diagnostics, Malmö
  • Pathology, Malmö
  • The Liquid Biopsy and Tumor Progression in Breast Cancer

ISBN/ISSN/Other

  • ISSN: 1573-7217