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Portrait of Magnus Dustler. Photo

Magnus Dustler

Researcher

Portrait of Magnus Dustler. Photo

Detection of calcification clusters in digital breast tomosynthesis slices at different dose levels utilizing a SRSAR reconstruction and JAFROC

Author

  • Pontus Timberg
  • Magnus Dustler
  • Hannie Petersson
  • Anders Tingberg
  • S. Zackrisson

Summary, in English

Purpose: To investigate detection performance for calcification clusters in reconstructed digital breast tomosynthesis (DBT) slices at different dose levels using a Super Resolution and Statistical Artifact Reduction (SRSAR) reconstruction method. Method: Simulated calcifications with irregular profile (0.2 mm diameter) where combined to form clusters that were added to projection images (1-3 clusters per abnormal image) acquired on a DBT system (Mammomat Inspiration, Siemens). The projection images were dose reduced by software to form 35 abnormal cases and 25 normal cases as if acquired at 100%, 75% and 50% dose level (AGD of approximately 1.6 mGy for a 53 mm standard breast, measured according to EUREF v0.15). An FBP algorithm adapted to DBT (called standard FBP) and a SRSAR reconstruction method utilizing iterative reconstruction filtering, and outlier detection using Maximum-Intensity Projections and Average-Intensity Projections) were used to reconstruct single central slices to be used in a free-response task (60 images per observer and dose level). Six observers participated and their task was to detect clusters and assign confidence rating in randomly presented images from the whole image set (balanced by dose level). Each trial was separated by one week to reduce possible memory bias. The outcome was analyzed for statistical differences using Jackknife Alternative Free-response Receiver Operating Characteristics. Results: The results indicate that it is possible to reduce the dose by 50% with SRSAR without jeopardizing cluster detection. Conclusions: The detection performance for clusters can be maintained at a lower dose level by using SRSAR reconstruction.

Department/s

  • Medical Radiation Physics, Malmö

Publishing year

2015

Language

English

Pages

941604-941604

Publication/Series

Medical Imaging 2015: Image Perception, Observer Performance, and Technology Assessment

Volume

9416

Document type

Conference paper

Publisher

SPIE

Topic

  • Radiology, Nuclear Medicine and Medical Imaging

Keywords

  • Digital Breast Tomosynthesis
  • Reconstruction Methods
  • JAFROC
  • FROC
  • Observer Performance
  • Dose
  • Perception

Conference name

Conference on Medical Imaging - Image Perception, Observer Performance, and Technology Assessment

Conference date

2015-02-25 - 2015-02-26

Status

Published

Research group

  • Medical Radiation Physics, Malmö

ISBN/ISSN/Other

  • ISSN: 0277-786X
  • ISSN: 1996-756X